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KMID : 0383119910390010051
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Journal of Aerospace Medicine
1991 Volume.39 No. 1 p.51 ~ p.68
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The Change of Amounts of Glycogen and Activities of Phosphoenolpyruvate Carboxykinase in Rat Liver by Hypoxia
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Kim Kyung-Sup
Lee Ki-Young
Kim Kun-Hong
Park Byoung-Ok
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Abstract
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The amounts of glycogen and the activities of PEPCK were measured in the livers of the rats after acute and chronic exposure to hypoxia while either fed ad. lib. or fasted for 24 hour. The hypoxia was induced by exposure to simulated altitudes of 27,500 feet for 2 hours/day, and the chronic hypoxia was produced by repeating same procedures as above for 30 days. At fasting state, the amounts of glycogen in the livers were depleted and were not changed significantly by hypoxia, under both acute and chronic exposure. However, the hypoxia decreased markedly those of glycogen in fed animals, although acute and chronic exposure did not show the differences significantly. This results suggest that the glycogenolysis in liver controbutes to maintaining the blood sugar consumed by anaerobic glycolysis in various tissue at hypoxic state. In control groups, the PEPCK activities at ´fasting state were at higher levels than at feeding state, but acute hypoxia increased the PEPCK activities to plateau at both fasting and feeding state. However in chronic hypoxia, the activities preserved a increased state, not further increased significantly by additional hypoxia, suggesting that the gluconeogenesis in the liver was increased by acute hypoxia and then adapted to increased state by chronic exposure to hypoxia.
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